Numerous genes associated with hereditary hearing loss have been linked to the cytoskeleton, including ACTG1 (DFNA20/26), which encodes gamma actin; DIAPH1 (DFNA1), which regulates actin filament polymerization; ESPN (DFNB36), involved in producing actin bundles; RDX (DFNB24), facilitating connections between actin filaments and stereocilia. This evidence concerns the gene ESPN and hearing loss disorder.