The PPI network suggested that 4a may target related proteins expressed by SRC, EGFR, CCND1, MTOR, MAPK1, PIK3CA, MMP9, MAPK8, MMP2, MAPK14, and other genes, which may be central targets for 4a to exert its anti-breast cancer effects. The gene discussed is MAPK8; the disease is breast carcinoma.