Recent studies of diffuse large B-cell lymphoma found that TIM-3+PD1+ TILs exhibited a transcriptomic signature of T-cell exhaustion, reduced proliferation, and impaired cytokine production, but these dysfunctions were restored by the blockade of PD1 or TIM-3 (167, 168). This evidence concerns the gene PDCD1 and diffuse large B-cell lymphoma.