A study in the MC38 colon cancer model has shown that PD-L1 blockade elevated the expression of both costimulatory receptors (ICOS) and coinhibitory receptors (LAG3 and PD-1) in TILs, thereby providing a new mechanistic rationale for coblocking LAG3 (211). The gene discussed is LAG3; the disease is malignant colon neoplasm.