The TNF antagonist etanercept can significantly enhance the killing effect of the ferroptosis inducer imidazole ketone erastin (IKE) on RA-FLSs, and the combination of the two restores synovial homeostasis by promoting FAPα+ fibroblasts ferroptosis and reducing the number of FAPα+ fibroblasts. The gene discussed is TNF; the disease is rheumatoid arthritis.