IL6 and hepatocellular carcinoma: IL-37 is able to promote tumor-associated macrophages (TAMs) polarization from tumor-promoting M2 to tumoricidal M1 phenotype via inhibiting IL-6/STAT3 signaling as shown in cultured HCC cells (HepG2 and Huh-7) and mouse-transplanted tumor model (89); and reduce the chemotaxis of Tregs that help tumor cells escape from immunosurveillance such as in lung adenocarcinoma A549 cells (90), through which effectively promote tumor rejection.