In addition, accumulated data suggested that the anomalous expression of IL-37 is involved in neoplasms progression and metastasis from different systems through various fashions, including regulating a series of cytokines and molecules in tumor-related signaling pathways (15–19), providing evidence that IL-37 was crucial in regulating the occurrence, pathogenesis and prognosis of human cancers. This evidence concerns the gene IL37 and neoplasm.