IL-37 is able to promote tumor-associated macrophages (TAMs) polarization from tumor-promoting M2 to tumoricidal M1 phenotype via inhibiting IL-6/STAT3 signaling as shown in cultured HCC cells (HepG2 and Huh-7) and mouse-transplanted tumor model (89); and reduce the chemotaxis of Tregs that help tumor cells escape from immunosurveillance such as in lung adenocarcinoma A549 cells (90), through which effectively promote tumor rejection. Here, IL37 is linked to hepatocellular carcinoma.