SIGIRR and hepatocellular carcinoma: In assays in HCC Hep3B cells in vitro and HCC mouse model constructed of Hepa1-6 cells in vivo, transduced IL-37 was also verified to enhance local infiltration of CD57+NK cells that expresses IL-18Rα and IL-1R8 chains in tumor sites to suppress tumorigenicity (15, 91).