Furthermore, a study on aging demonstrated that IL-37 abrogated the activation of TNF-α-induced NF-κB in T cells and significantly decreased the expression of PD-1 (a classical coinhibitory factor in tumor-associated immune escape) on effector CD4+ and CD8+ T cells surface to alleviate T cells senility (75, 92). The gene discussed is CD8A; the disease is neoplasm.