In another model with DSS-induced IBD, IL-37 protein was expressed on T cells in human IL-37 transgenic (hIL-37tg) mice, and the decreased mRNA expressions of pro-inflammatory cytokines like IFN-γ, IL-1β and TNF-α in colon tissues, disease activity index (DAI) and macroscopic damage score were observed. The gene discussed is IFNG; the disease is inflammatory bowel disease.