IL6 and cancer: Pan-cancer gene set enrichment analysis showed that high expression of OAS1 is linked to the activation of multiple signaling pathways, such as the interferon α (NES = -2.4, FDR <0.001) and γ signaling pathways (NES = -2.4, FDR <0.001), as well as the IL6-JAK-STAT3 signaling pathway (NES =-1.98, FDR = 0.01) (Figure 7D).