CD14 and HIV-1 infection: In contrast, in patients with acute HIV-1 infection, increased proportions of Foxp3+Helios+CD45RA+ Treg were reported along with decreased frequencies of CD14++CD16+ (intermediate) monocytes and increased proportions of PD-1+ cells among both CD14++CD16+ and CD14+CD16++ (non-classical) monocytes (9).