It was shown 20 years ago that human CD4+CD25+ Treg suppressed Vα24+NKT cell proliferation, cytotoxicity to tumor cells lines and cytokine production (IFN-γ, IL-4, IL-10, and IL-13) upon stimulation by α-galactosylceramide (αGalCer)-pulsed Mo-DCs. This evidence concerns the gene CD4 and neoplasm.