have shown that human TGF-β-induced Treg suppressed IL-5 and IL-13 secretion by ILC2 through contact-dependent (ICOS/ICOS-L) and soluble (TGF-β and IL-10) mediators to control airway inflammation in a humanized model of ILC-2-dependent asthma. The gene discussed is TGFB1; the disease is asthma.