The results suggested that the expression of AFP before treatment (HR 1.950, 95%CI 1.271-2.992, P = 0.002), giant HCC (HR 2.211, 95%CI 1.397-3.499, P = 0.001), PVTT type (HR 2.211, 95%CI 1.859-4.788, P < 0.001), extrahepatic metastasis (HR 1.921, 95%CI 1.177-3.133, P = 0.009), radiotherapy for PVTT (HR 0.227, 95%CI 0.135-0.328, P < 0.001), and reduction of PVTT (HR 0.107, 95%CI 0.049-0.233, P < 0.001) were the influencing factors of PFS (Table 4). Here, AFP is linked to hepatocellular carcinoma.