Sex, age, smoking, alcohol consumption, diabetes, hypertension, cardiovascular disease, child-pugh grade, ECOG-PS score, whether B viral hepatitis, whether cirrhosis, AFP lever before treatment (< 400ng/ml or ≥400 ng/ml), HBV-DNA lever (0-1×103 or >1×103), whether giant HCC, PVTT type (I-II or III-IV), whether extrahepatic metastasis, whether PVTT was treated with radiotherapy, and whether there was reduction of PVTT were analyzed by univariate Cox analysis. This evidence concerns the gene AFP and cardiovascular disorder.