In contrast, folate-S0456 was aggressively captured by CD45+CD11b+F4/80+FRβ+ cells (tumor-associated macrophages and myeloid derived suppressor cells) (Figure S5D), but not by CD45+CD4+CD25+FRδ+ Tregs, whereas Ral-S0456 was primarily accumulated by FRδ+ Tregs and to a lesser extent by CD4+CD25-FRδ+ cells (memory T cells, Figure S5C) and CD45+CD11b+F4/80+FRβ+ myeloid cells. Here, CD4 is linked to neoplasm.