Whether this enhanced potency was a consequence of the specific syngeneic tumor model (i.e., MB49 versus 4T1) or the switch from balb/c to C57Bl/6 mice was not investigated, but the data clearly confirmed that Ral-TLR7-1a mediated reprogramming of tumor Tregs exerts a profound effect on tumor growth even in the absence of any contribution of the drug to suppression of tumor-infiltrating myeloid cells. The gene discussed is RALA; the disease is neoplasm.