When considered together with the observations that Tregs comprised <1% of total cells in the tumor masses examined and that tumor-associated macrophages and CD8+ effector T cells are simultaneously repolarized to more inflammatory phenotypes, presumably as a consequence of Treg repolarization, these data argue that Tregs make a disproportionately large contribution to immunosuppression in the tumor TME. Here, CD8A is linked to neoplasm.