Previous studies have reported some genetic background for the development of ILD in DM, such as gene polymorphisms (STAT4 rs7574865, TNFAIP3 rs2230926 and rs5029939, ANKRD55 rs7731626, and PLCL1 rs6738825 and rs7572733, etc) and differential expressed lncRNAs (37–41). This evidence concerns the gene PLCL1 and dermatomyositis.