Lactiplantibacillus plantarum 0111 oral pretreatment up-regulates ISG transcription 7 days after H9N2 infection while elevating CD3+CD4+TNF-α+T lymphocyte percentage and CD3+CD8+TNF-α+T lymphocyte percentage in the spleen and enhancing adaptive immunity to the virus (65). The gene discussed is TNF; the disease is infection.