Peroxisome proliferator-activatedreceptor (PPAR)-gamma is regarded as a transcription factor with a well projected role in adipocyte differentiation [1].The Ala allele of the common Pro12Ala polymorphism in the isoform PPAR-gamma 2 possesses a nexus with a lessened risk for type 2 diabetes mellitus (T2DM) .Inaddition to adipocyte differentiation, other events namely lipid, glucose homeostasis, and insulin sensitivity are considered as cardinal cellular events that areinfluenced by the transcription factor PPARγ. The gene discussed is PPARG; the disease is diabetes mellitus.