Furthermore, somestudies indicate that elevated AIP in T2DM patients could increase cardiovascular disease risk with poor prognosis[20].Thepresent study is unique in the sense that we had attempted to project a relationship involving insulin resistance, inflammatory mediators (hs-CRP, haptoglobin,Ferritin and adiponectin), with reference to the wild type and heterozygous variants of PPARγ gene. The gene discussed is HP; the disease is type 2 diabetes mellitus.