We made a humble attempt to compare and elucidate the insulin resistance in obese and overweight T2DMpatients (males) through the assessment of biochemical markers of inflammation and atherogenicity such as ferritin, hs-CRP, Haptoglobin with reference to thegene polymorphism (Pro12 Ala) of peroxisome proliferator-activated receptor gamma (PPAR- γ). This evidence concerns the gene HP and Insulin resistance.