Our study with 180 obese and overweight South Indian T2DM patients indicated that about 92.2% of overweight and 62.2% of obese T2DM patients had wild(CC) PPAR-γ 2 polymorphism while heterozygous (CG) PPAR-γ polymorphism was observed in 7.78% of overweight and 37.78% of obese T2DM patients(Table 1). The gene discussed is PPARG; the disease is type 2 diabetes mellitus.