IDH2 and central nervous system cancer: Clinically, high-ANG was shown to be significantly relevant to a range of malignant clinicopathological characteristics, including elderly age, GBM histology, higher WHO-grade, wildtype IDH, methylated MGMT promoter, non-codeleted 1p19q, mesenchymal molecular subtype, shorter OS, and unfavorable censor outcome, suggesting the close relationship between ANG and aggressive phenotypes of gliomas.