Moreover, ANG is supposed to play an essential role in a series of malignant phenotypes, including angiogenesis (23, 24, 26, 30, 34), proliferation (7, 8, 11, 31, 35), migration (7, 25), invasion (32), metastatsis (16), recurrence (33), epithelial-mesenchymal transition (EMT) (18, 22), radiochemotherapy resistance (14, 19, 28), and tumor-associated immunity (9, 17). The gene discussed is ANG; the disease is neoplasm.