MDM4 and neoplasm: High-ANG was significantly associated with high amplification in multiple oncogenic drivers, including EGFR, CDK4, FIP1L1, PDGFRA, CHIC2, PIK3C2B, MDM4, MBD6, and DDIT3 (53), and with more frequent deletions in tumor-suppressing genes like CDKN2A, CDKN2B, MTAP, MLLT3, and PTEN (54).