To integratively demonstrate and characterize the ANG expression in whole-grade gliomas molecularly and clinically, we conducted this comprehensive analysis based on a total of 1,323 glioma samples from three independent glioma datasets of CGGA301, TCGA, and CGGA325, with which we would like to perform 3-dataset cross-validation to generate more robust results (51–53). This evidence concerns the gene ANG and central nervous system cancer.