IL6 and non-small cell lung carcinoma: Based on the above results, we hypothesized that cinobufagin could reverse IL-6-induced nuclear translocation of P-STAT3, the immunofluorescence staining for STAT3 phosphorylation in NSCLC cells shows that most P-STAT3 was primarily localized to the cytoplasm and then translocated to the nucleus in response to IL-6 stimulation.