CYP3A4 and cholangitis: Demographics and clinical characteristics of patients with switching and non-switching IS drugs were listed in Table 2, and significant differences were found in various factors including recipient CYP3A4 genotype (p < 0.001), cholangitis before LT (p = 0.029), serum albumin (p = 0.044), surgical type (p = 0.018), graft volume reduction during the operation (p = 0.008), types of IS drugs (p < 0.001), the addition of MMF (p < 0.001), donor CYP3A4 genotype (p < 0.001), and donor age at LT (p = 0.021) between the two groups (Table 2).