Similar to the positive roles of m6A erasers in DLBCL, the increased expression level of METTL3 is found in DLBCL tissues and cell lines, and silencing METTL3 expression in DLBCL cells inhibits cell proliferation rate by abating the m6A methylation and total mRNA level of pigment epithelium-derived factor (PEDF) 147, indicating that inhibition of m6A methylation likely suppresses tumorigenic properties of DLBCL cells. This evidence concerns the gene METTL3 and diffuse large B-cell lymphoma.