Velichutina et al. reported that EZH2-bound promoters are aberrantly hypermethylated in diffuse large B-cell lymphoma cells (DLBCL), and knockdown of EZH2 in diffuse DLBCL resulted in acute cell cycle arrest at the G 1/S transition by increasing expression of several key cell cycle-related tumor suppressor genes, indicating that EZH2 expression is closely associated with B lymphomagenesis 130. The gene discussed is EZH2; the disease is diffuse large B-cell lymphoma.