For instance, loss of METTL3 or METTL14 in tumor cells increased tumor-infiltrating CD8+ T cells and promoted secretion of IFN-γ and CXCL10 by stabilizing the STAT1 and IRF1 mRNA via YTHDF2, thus sensitizing microsatellite instability-low CRC tumors to PD-1 treatment in vivo 110. Here, IRF1 is linked to neoplasm.