In contrast, the addition of entinostat to N-803 plus vaccine suppresses significant tumor growth, correlating with increased expression of genes associated with tumor inflammation, enhanced infiltration of activated CD8+ T cells with maximal GzmB as well as increased serum IFNγ in the TME of TNBC and CRC murine carcinoma models 124. This evidence concerns the gene CD8A and colorectal carcinoma.