For example, the neutrophil-enriched pancreatic cancer clones increase CXCL1 expression that is mediated at the epigenetic level via a combination of more accessibility of the promoter region, enrichment of the active H3K4me3 histone marker and activity of c-Myc that governs CXCL1 expression 174. The gene discussed is CXCL1; the disease is familial pancreatic carcinoma.