ODC1 and neoplasm: In an immunosuppressive mouse model of aggressive high-grade serous ovarian cancer, Travers et al. found that the combination of 5-Aza and DFMO (an ornithine decarboxylase inhibitor) significantly decreases immunosuppressive cells such as M2 macrophages and increases tumor-killing M1 macrophages, resulting in decreased tumor burden and prolonged survival 163.