NFKB1 and cancer: Current data 32, 33 also confirm that the oncogenic range of Notch signaling is partly due to its crosstalk with other signaling pathways, such as NF-kB, Hedgehog, JAK/STAT, MAPK, HIF-1α, Wnt, TGF-p, VEGF, PI3K/Akt, Ras, etc. In fact, based on the overwhelming evidence for the role of Notch signaling in cancer, this pathway has clearly become an important target for cancer therapy.