Although anoikis is mediated by multiple signaling pathways such as the Integrin-FAK, PI3K/Akt and MAPK pathways 23, 37, 38, studies have highlighted the crucial role of the EGFR pathway in conferring anoikis resistance to tumor cells in peripheral blood and facilitating metastasis 39-43. The gene discussed is PTK2; the disease is neoplasm.