Conversely, viral infection-induced automethylation of PRMT7 at R32 alleviates the suppression of MAVS activation and promotes its interaction with the MAVS-recruited ubiquitin E3 ligase SMURF1, leading to K48-linked polyubiquitination and proteasomal degradation of PRMT7 114. This evidence concerns the gene PRMT7 and viral infectious disease.