For instance, upon amino acid stimulation, cyclin-dependent kinase 5 (CDK5) phosphorylates PRMT1 at S307 to promote its transportation to lysosomes in the cytoplasm for the methylation of WDR24 and subsequently activates the mTORC1 pathway, leading to tumor growth 83 (Figure 3A). Here, PRMT1 is linked to neoplasm.