In addition, the response of ZIP12 to hypoxia was significant in other species, such as cattle and human, showing increased expression of ZIP12 protein when under hypoxic conditions; in the lung tissues from chronic Fe-deficient rats; rats exposed to monocrotaline (MCT), as well as in patients with IPAH 156. This evidence concerns the gene SLC39A12 and idiopathic pulmonary arterial hypertension.