The knockdown efficiency of Lenti-shXPOT-transfected MDA-MB-231 and MDA-MB-468 cells was demonstrated by western blotting (Fig. 2D), which revealed that XPOT knockdown prominently inhibited tumor growth in the xenograft tumor model established with MDA-MB-468 cells (Fig. 2E-G). This evidence concerns the gene XPOT and neoplasm.