Consistent with the possibility that caspase-1 plays a role in GBS-induced macrophage death in our experimental system, we also observed that cell death could be significantly reduced at the 48 hour time point, albeit modestly, by treating the THP-1 cells with the pan-caspase inhibitor Z-VAD-fmk prior to infection with GBS (Figure S6). Here, CASP1 is linked to infection.