AKT1 and infection: Our data demonstrating that treatment with a PI3K-Akt pathway inhibitor reduces both phagocytic uptake of GBS one hour post-infection as well as intracellular survival of GBS 24 hours post-infection support the hypothesis that the PI3K-Akt pathway contributes to the initial uptake and intracellular survival of GBS within macrophages, though the precise mechanisms involved require more exploration.