Moreover, our study found that metformin can restore damaged autophagic flux, enhance the vitality of fibroblasts from patients with UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) myopathy, reduce the rate of apoptosis, and thus play a protective role in GNE myopathy (10). The gene discussed is GNE; the disease is myopathy.