AGT and abdominal aortic aneurysm: One study demonstrated that in an angiotensin II (Ang-II)-induced ApoE−/− mouse abdominal aortic aneurysm model, metformin inhibited PI3K/AKT/mTOR pathway activation, and reduced Ang-II-induced autophagy-related protein levels to inhibit aortic dissection, thus, preserving aortic elastin structure and reducing collagen loss and aortic cell apoptosis (62).