Yang et al. (23) prospectively collected preoperative blood samples from 184 UIA patients and divided them into high and low-risk groups based on propensity matching score and ELAPSS score; results showed patients with higher serum levels of IL-15, monocyte chemotactic protein-1 (MCP-1), and TNF-β were associated with an increased risk of aneurysm growth, and elevated IL-15 and TNF-β serum levels might indicate IA progression. This evidence concerns the gene LTA and aneurysm.