COVID-19 enter cellular access by angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) which both of them are expressed in many endocrine glands that’s why this virus causes thyroid dysfunction such as thyroiditis, insufficient pancreatic insulin secretion and hyperglycemia or ketoacidosis, adrenal infarction, and disruption of sex hormones in both sexes (33). This evidence concerns the gene INS and Hyperglycemia.