In mice with an impaired SPM production mechanism, i.e., those deficient in 5-LOX, infection with Borrelia burgdorferi caused a similar pattern of arthritis development as it did in wild type counterparts, the key feature, however, was that the lack of resolvins and lipoxins impaired the ability of the host to resolve arthritis, giving rise to chronic disease, the inflammatory response of which persisted long after the causative agent was cleared (60). This evidence concerns the gene ALOX5 and infection.