Mouse strains with other targeted genetic modifications at different locations of the Apc gene, such as ApcMin/850, ApcΔ716, Apc1638N, Apc1638T, ApcΔ468 and ApcΔ474, were developed to allow reproduction of disease models closer to CRC in humans and study the role of certain regions of the APC gene in the development of cancer. Here, APC is linked to colorectal carcinoma.