According to Ye et al. (2020)KRAS, KIT, PIK3CA, MET and EGFR are among the most frequently mutated oncogenes, and TP53, APC, CDKN2A, STK11 and FBXW7 are the most frequently mutated tumor suppressor genes in patients with CRC. The gene discussed is APC; the disease is colorectal carcinoma.