COL1A2 and osteogenesis imperfecta: Cheng et al. (2019) developed a sucrose acetate isobutyrate (SAIB) solution as an effective carrier to deliver BMP-2 into the reamed tibias through intraosseous injection, resulting in an increase in cortical bone thickness in a type of OI mice (Col1a2+/G610C). In another study, a small cubed acellular collagen sponge was used as a BMP-2 sustained-release technique to treat tibial fractures in Col1a2+/G610C mice, increasing trabecular bone (O’Donohue et al., 2022).