STAT3 and renal cell carcinoma: Chae et al. (2020) also reported that Thymoquinone effectively prevented the phosphorylated form of STAT3 from entering the nucleus and binding to DNA to activate the transcription of target genes. Similarly, SIRT1 destabilized STAT3 through the ubiquitin-proteasome pathway, resulting in a decreased STAT3-dependent FGB expression, which in turn inhibited RCC cell proliferation (Chen et al., 2019).