In this review, we present some allergic-like reactions that can be life-threatening, such as (1) SFP, (2) bradykinin-induced angioedema, (3) IgE-independent angioedema, such as opioid-induced angioedema, and (4) non-steroidal anti-inflammatory drug (NSAID)-induced hypersensitivity and angioedema. Here, IGHE is linked to angioedema.