Genetic variations in the grinb2 gene, which codes for the GluN2B subunit of the NMDA receptor, have been consistently associated with several neurological conditions, such as West syndrome, intellectual disability accompanied by focal epilepsy, developmental delay, macrocephaly, brain plasticity, infantile spasms, and Lennox-Gastaut syndrome. This evidence concerns the gene GRIN2B and Lennox-Gastaut syndrome.