AD, one of the major cause of dementia, is a degenerative brain disease characterized by the aggregates of extracellular β-amyloid (Aβ) plaques and intracellular tau protein, leading to neurofibrillary tangles, neuronal loss and cell death (Parihar and Hemnani, 2004; Citron, 2010). The gene discussed is MAPT; the disease is Alzheimer disease.