LEP and diabetes mellitus: Decrease TC, TCH, TG and LDL-C, inhibit FA, LDH, and ALT and increase the HDL-C to TC ratio, elevate HDL, NO and SOD activity levels, Clean fat accumulation in liver tissue caused by diabetes, Induced p-AMPK, Inhibit the expression of p-ACC, Modulation of LPL; Inhibit secretion of Leptin, PAI-1