EFEMP1 and hemorrhoid: This abnormality may be related to the reduced expression of Fibulin-3 and 5 in hemorrhoid tissues (Sun, 2014; Xiao, 2016; Zhong, 2016; Jin et al., 2017; Sun et al., 2018).It was found that not only can Buzhong Yiqi Decoction improve the prolapse symptoms of prolapsed hemorrhoids, but it can also increase the expression of Fibulin-3 and 5 (Sun, 2014; Xiao, 2016; Sun et al., 2018).