EFEMP1 and hemorrhoid: Zhong (2016); Jin et al. (2017) also found that different doses of Astragalus in Buzhong Yiqi Decoction can improve the symptoms of prolapse and heaviness in the anus of patients with prolapsed internal hemorrhoids, and can increase the expression of Fibulin-3. In animal research, (Jiang and Liang, 2018) found that in a rat hemorrhoid model induced by acetic acid, Modified Buzhong Yiqi Decoction can relieve rat hemorrhoid perianal ulceration and edema, and significantly increase the expression of Fibulin-5.