Apart from its insulin-stimulating effects, GIP, during hypoglycemia, stimulates glucagon secretion (Gasbjerg et al., 2018), enhances the absorption of fatty acids in adipocytes, increases the deposition of triglycerides in subcutaneous adipose tissue (Boer et al., 2022) and decreases bone reabsorption (Gasbjerg et al., 2018). The gene discussed is INS; the disease is Hypoglycemia.