Pro-inflammatory cytokines can accelerate glycolysis (48–50) and CAF-derived HIC-5 increases the release of cytokines like CCL2, which may cause the local accumulation of energy-rich metabolites Altogether, CAF-derived HIC-5 can accelerate cancer growth by modulating metabolic signalling pathways, promoting inflammatory states and upregulating glycolysis, thus providing metabolites to cancer cells. This evidence concerns the gene CCL2 and cancer.