CAF-derived POSTN stimulates the activity of a disintegrin and metalloproteinase 17 (ADAM17) by activating the integrin αvβ3 or αvβ5–ERK1/2 pathway, thus contributing to the growth, proliferation, invasion and metastasis of ESCC. The gene discussed is MAPK3; the disease is esophageal squamous cell carcinoma.