By the NF-B, AKT, and ERK signaling pathways, MT2A boosts the synthesis and release of IGFBP2 in CAF-like cells and encourages the migratory and invasive properties of ESCC cells.Additionally, MT2A takes part in tumour cell expansion, invasion and migration in ESCC. The gene discussed is MT2A; the disease is esophageal squamous cell carcinoma.