STAT3 and anaplastic large cell lymphoma: In BIA-ALCL pathogenesis, the chronic inflammation elicited by the implant and the bacteria biofilm growing on its surface is thought to play a major role in favoring chromosomal instability, dysregulation of the epigenetic machinery, and mutations of genes of the JAK-STAT3 signaling responsible for the transformation of normal lymphocytes into lymphoma cells (22, 27, 28, 94, 95).