Ultimately, they identified a significant sub-network of ten genes, including GUCA2B, GUCA2A, GCG, BEST4, UCN3, SST, NPY, PYY, OTOP2, and TMEM82. However, expression levels of GUCA2B and GUCA2A have no correlation with the OS of patients with CRC in this study either (58). The gene discussed is OTOP2; the disease is colorectal carcinoma.