The HBV antigen HBx, a protein essential for viral replication, was present in the lymphoma cells in 48.9% of HBsAg+ DLBCL patients; additionally, the HBV antigen Pre-S2, a component of HBsAg, was detected in the lymphoma cells of 57.2% HBsAg+ DLBCL patients. Notably, the authors also showed that the presence of HBx antigen in DLBCL cells was associated with high MYC expression (p = 0.0302). The frequency of MYC gene rearrangement was significantly higher in HBV+ DLBCL cases than in the HBV- group. This evidence concerns the gene MYC and lymphoma.