MTOR and tauopathy: Notably, pharmacological studies using autophagy inducers such as trehalose and dimethyl sulfoxide, or mTOR inhibitors like rapamycin, bexarotene, and lactacystin in animal models of human tauopathy support the notion that autophagy involvement in Tauopathy may confer beneficial effects (Congdon et al., 2012; Schaeffer and Goedert, 2012).