Similar to CD4 Tconv, the CAD‐associated increase in KLRG1 expression in CD8 T cells was limited to the cytotoxic KLRG1+CD27− subset [38.7% ± 20.5% vs 30.2% ± 16.4%, P = 0.030], and again these changes were present in both the SMuRFless subjects and in those who had traditional CAD risk factors. This evidence concerns the gene CD8A and coronary artery disorder.