An increment in canonical WNT signaling also characterizes the muscles of DMD patients, as disclosed by the quantification of known targets of the WNT signaling pathway (i.e., Axin2 and TGFβ2) in the interstitial space of human muscle biopsies (Appendix Fig S1B and C). This evidence concerns the gene TGFB2 and Duchenne muscular dystrophy.