Our previous study demonstrated the effect of FAM3C or LIFR knockdown in shPCBP1 cells by revealing that increased self-renewal in vitro and decreased tumor burden and metastases in vivo were dependent on FAM3C-induced LIFR-dependent pSTAT3.7 Preclinical studies by other groups have likewise demonstrated that LIFR expression promotes breast cancer progression. This evidence concerns the gene LIFR and breast carcinoma.