Also, NT-proBNP concentrations correlate with signs of hyperdynamic circulation (stroke volume, cardiac output, left atrial volume, reduction in systemic vascular resistance - decrease in systolic, diastolic, and mean arterial pressure) in patients with decompensated liver cirrhosis and do not correlate with a decreased ejection fraction as it is the case in heart failure. This evidence concerns the gene NPPB and heart failure.