After Bonferroni-correction, according to the IVW and weighted-median analysis, the presence of genetically high IL-17A/IL-17RA were associated with increased risk of RA (IL-17A(OR = 1.095; 95% C.I., 0.990–1.210, p.adj = 0.013), IL-17RA(OR = 1.113, 95%CI = 1.006–1.231, p.adj = 0.006)).. The gene discussed is IL17A; the disease is rheumatoid arthritis.