In the multivariable analysis in cohort 1, preoperative predictors of HRS or multiple LRS recurrence were CEA ≥ 5 ng/ml (odds ratio [OR], 1.41; 95% CI:1.12–1.77; p = 0.004), PET maxSUV ≥ 3.2 (OR, 5.09; 95% CI:3.66–7.08; p < 0.001), CT tumor size ≥ 2.4 cm (OR, 1.96; 95% CI:1.50–2.56; p < 0.001),and clinical nodal metastasis (OR, 2.00; 95% CI:1.53–2.60; p < 0.001) (Table 3). This evidence concerns the gene CEACAM5 and neoplasm.