Mechanically, MYL9 can regulate the secretion of CCL2 and TGF-β1 of CAFs through ERK 1/2 by binding to IQGAP1, and the secreted CCL2 and TGF-β1 promote the progression of CRC through the PI3K-AKT pathway. This evidence concerns the gene MYL9 and colorectal carcinoma.