TGFB1 and colorectal carcinoma: Secondly, MYL9 in CAFs can regulate the secretion of CAFs cytokines and chemokines such as CXCL1, CCL2, IL-10, and TGF-β1, which in turn recruit M2 macrophages and inhibit the activation of dendritic cells to induce an immunosuppressive microenvironment in CRC.