Therefore, MYL9 located in CAFs can interact with IQGAP1 to regulate the secretion of TGFβ1 and CCL2 through ERK 1/2, and CCL2 and TGFβ1 can not only affect the immune microenvironment of CRC, but can also promote the proliferation of CRC through the coordination of PI3K/AKT. Here, AKT1 is linked to colorectal carcinoma.