Therefore, Insulin resistance signaling pathway and inflammatory signaling pathway are the main pathways, such as AMPK, PGC-1α, NLRP3, STING and TGF-β, which affect mitochondrial homeostasis and glycogen consumption, thus forming inflammation and obese sarcopenia from the perspective of mitochondria [40, 61, 62, 68, 74, 75]. Here, STING1 is linked to sarcopenia.