Therefore, targeting ATTR-CM screening in the presence of HF symptoms based on risk factors for the wild type form (male, older than 60) [6–9] or associated clinical conditions (including carpal tunnel syndrome, valvulopathies, [10], conduction disorders, arrhythmias as atrial fibrillation, polyneuropathy [11], among others) may identify the majority of ATTR-CM in western countries. The gene discussed is TTR; the disease is cardiac arrhythmia.