NOTCH3 and snowflake vitreoretinal degeneration: Also, one study evaluating patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a NOTCH3 mutation-related SVD, reported that similar small-vessel alterations can be found on myocardial specimens and in the brain (Lesnik Oberstein et al. 2003).